Endocrine Abstracts

Empty sella is characterized by the radiological appearance of an enlarged or deformed sella turcica which is completely or partially filled with cerebrospinal fluid resulting in a displacement of the normal pituitary gland. Primary empty sella (PES) refers to the empty sella appearance of unknown etiology, diagnosed after excluding a history of previous pituitary pathology. The prevalence of hypopituitarism in empty sella syndrome varies between 2 and 32% in different publish...

Background: The advances in next-generation sequencing (NGS) technologies and bioinformatic analysis have shed light on genetic alterations, either of germline or somatic origin, in many disorders, including adrenocortical diseases. However, our knowledge on genomic characteristics in benign adrenal tumors of serendipitous discovery (adrenal incidentalomas) remain scarce.The aim of this study was to understand the pathogenic role of germline variants in adrenal incidentalomas....

Background: Ketoconazole is a steroidogenesis inhibitor approved in Europe for the treatment of endogenous Cushing’s syndrome (CS) based on retrospective studies published over 3 decades. We present interim data from the first prospective observational, multicenter, international study on ketoconazole, a non-interventional PASS (Post-Authorization Safety study) requested by EMA at the time of registration to confirm ketoconazole good tolerance and effectiveness. This stud...